In vitro antibacterial, real sputum samples, and clinical cases jointly constitute multidimensional evidence
Introduction
The study evaluates the antibacterial activity of mulberry dandelion beverage against multidrug-resistant bacteria through in vitro antibacterial experiments, real sputum sample testing, and clinical case observations. The research shows that it exhibits inhibitory effects on Pseudomonas aeruginosa, carbapenem-resistant Acinetobacter baumannii, penicillin-resistant Streptococcus pneumoniae, etc., and possesses antibacterial characteristics distinct from traditional antibiotics.
The related paper has been published on the preprint platform: "Research Square" link: https://www.researchsquare.com/article/rs-4956501/v1
In vitro test paper, mulberry dandelion soup effectively inhibits multiple superbugs.
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Real-world observation from severe infection, inflammatory indicators, nutritional status to anti-infection outcome
Introduction
The study focuses on a critically infected patient infected with multidrug-resistant Klebsiella pneumoniae. The patient had undergone multiple ICU treatments and various antibiotic therapies, yet infection control remained challenging. Continuous culture and follow-up showed that during the 12th to 18th week of hospitalization and the 6-week follow-up after discharge, multidrug-resistant Klebsiella pneumoniae was no longer detected, and lung inflammation and pleural effusion gradually transitioned from extensive lesions to basic absorption. This study provides real-world evidence for the long-term control of multidrug-resistant bacteria in complex critical infection scenarios.
The related paper has been published on the preprint platform: "SSRN" link: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4967550
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Observation of pathogen exit from long-term multidrug-resistant Acinetobacter baumannii infection
Introduction:
The study focuses on a highly concerning nosocomial infection pathogen—multidrug-resistant Acinetobacter baumannii. The patient's infection persisted for over a year, with limited effects from conventional anti-infective treatments. The paper records that after receiving herbal nutrition intervention, cultures on May 17 and June 8 no longer detected Acinetobacter baumannii; infection reappeared during a brief discontinuation, and after resuming intervention, the culture on June 19 showed no bacterial growth, with four subsequent cultures continuing to support the absence of pathogen detection. This study presents the continuous changes in the process of long-term dominant drug-resistant pathogens transitioning from persistent presence to infection exit.
The related paper has been published on the preprint platform: "ChinaXiv" link: https://chinaxiv.org/abs/202501.00193
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From dominant pathogens, drug sensitivity changes to improved infection ecology in later tracking
Introduction
The study records the long-term pathogen evolution of two late-stage ALS patients under severe infection. Case A initially had long-term detection of multidrug-resistant Acinetobacter baumannii, accompanied by recurrent Pseudomonas aeruginosa infections; subsequently, the original dominant drug-resistant pathogens gradually exited the continuous dominant state, and the newly emerged Klebsiella pneumoniae and Escherichia coli did not exhibit multidrug-resistant phenotypes overall. Case B's highly drug-resistant Klebsiella pneumoniae did not recur, and the subsequently detected Pseudomonas aeruginosa remained sensitive to multiple common drugs such as amikacin, cefepime, imipenem, and meropenem. The study presents real-world clues of superbug infections transitioning from "long-term high drug resistance dominance" to "later reduced drug resistance burden, easier infection control".
The related paper has been published on the preprint platform: "ChinaXiv" link: https://chinaxiv.org/abs/202605.00009